1. Global DNA Synthesis Market Definition
The global DNA synthesis market revenue is projected to reach $1,459.33 million in 2025 with a CAGR of approximately 12.5% from 2025 to 2030.
DNA synthesis is a critical tool in modern biotechnology, enabling the creation of precise genetic sequences for applications ranging from gene therapy and vaccine development to forensic science. The ability to synthesize DNA has revolutionized the way scientists approach genetic research, allowing for the rapid development of customized genetic constructs. This technology is essential for advancing synthetic biology, personalized medicine, and the development of novel therapeutic agents.
The market’s growth is further supported by the increasing prevalence of genetic disorders and the need for effective treatments. DNA synthesis plays a crucial role in the development of gene therapies, which involve the introduction of synthetic DNA into cells to correct genetic defects. Additionally, the market benefits from advancements in next-generation sequencing technologies, which have reduced the cost and increased the efficiency of DNA synthesis market.
Global DNA Synthesis Market Value (M USD) in 2025
2. Driving Factors of Global DNA Synthesis Market
Increasing Demand for Gene Therapy: Gene therapy is a rapidly growing field that relies heavily on DNA synthesis. The ability to create precise genetic constructs is essential for developing therapies that target specific genetic disorders. As the prevalence of genetic diseases increases, so does the demand for effective treatments, driving the market for DNA synthesis.
Advancements in Synthetic Biology: Synthetic biology involves the design and construction of new biological systems using synthetic DNA. This field has seen significant advancements in recent years, with researchers developing new methods for creating customized genetic sequences. These advancements have expanded the applications of DNA synthesis, driving market growth.
Personalized Medicine: Personalized medicine involves tailoring medical treatments to individual patients based on their genetic makeup. DNA synthesis is a key component of this approach, as it enables the creation of customized genetic constructs for targeted therapies. The growing interest in personalized medicine is driving the demand for DNA synthesis services.
Technological Innovations: Advances in DNA synthesis technologies, such as next-generation sequencing and enzymatic DNA synthesis, have made the process faster, more accurate, and more cost-effective. These innovations have expanded the market’s potential applications and reduced barriers to entry for new players.
3. Limiting Factors of Global DNA Synthesis Market
High Costs: DNA synthesis involves complex chemical reactions and requires advanced equipment. The cost of raw materials, such as reagents and enzymes, contributes to the overall expense of the process. Additionally, continuous advancements in technology require significant investment in research and development, further increasing costs.
Synthesis Errors and Quality Control: The DNA synthesis process is not error-free, and mistakes can lead to inaccurate DNA sequences. Ensuring high-quality control standards and minimizing synthesis errors are ongoing challenges for companies in this sector. Maintaining accuracy is particularly important for applications like gene therapy and diagnostics, where precision is critical.
Regulatory Challenges: The biotechnology industry is highly regulated, and DNA synthesis is no exception. Companies must navigate complex regulatory frameworks to bring their products to market. These regulations can be time-consuming and costly, posing a barrier to market entry for some players.
Ethical and Safety Concerns: The use of synthetic DNA raises ethical and safety concerns, particularly in the context of gene editing and genetic modification. Public perception and regulatory scrutiny of these technologies can impact market growth, as companies must address potential risks and ensure the safety of their products.
4. Analysis of Different Product Types in the DNA Synthesis Market
Oligonucleotide synthesis involves the creation of short DNA or RNA sequences, typically used as primers and probes in molecular biology. These sequences are essential for applications such as PCR, sequencing, and gene expression analysis. In 2025, the market revenue for oligonucleotide synthesis is projected to reach $773.74 million. This segment is characterized by its versatility and wide range of applications, making it a cornerstone of modern genetic research.
Gene synthesis, on the other hand, involves the creation of longer DNA sequences, often used to construct entire genes or gene libraries. This segment is crucial for applications such as gene therapy, synthetic biology, and the development of recombinant proteins. The market revenue for gene synthesis in 2025 is expected to reach $685.58 million. Gene synthesis offers a higher level of customization and complexity compared to oligonucleotide synthesis, making it a powerful tool for advanced genetic engineering.
Analysis of Different Applications in the DNA Synthesis Market
Research and Development is a critical application area for DNA synthesis, encompassing activities in academic institutions, biotechnology companies, and pharmaceutical firms. In 2025, the market revenue for R&D applications is projected to reach $441.82 million. This segment is characterized by its focus on fundamental genetic research, the development of new technologies, and the exploration of novel biological systems.
Diagnostics is another significant application area for DNA synthesis, focusing on the development of genetic tests and diagnostic tools. In 2025, the market revenue for diagnostics applications is expected to reach $436.81 million. This segment is crucial for the early detection and monitoring of genetic disorders, infectious diseases, and cancer.
Therapeutics represents one of the most promising application areas for DNA synthesis, focusing on the development of gene therapies and other DNA-based treatments. In 2025, the market revenue for therapeutics applications is projected to reach $580.70 million. This segment is characterized by its focus on the development of novel therapeutic agents, including gene therapies, vaccines, and recombinant proteins.
The growth of therapeutic applications is driven by the increasing demand for effective treatments for genetic disorders and other diseases. Advances in DNA synthesis technologies have enabled the development of more precise and efficient gene therapies, driving the expansion of this segment. Additionally, the expanding field of personalized medicine relies heavily on therapeutics to develop targeted treatments that address the specific genetic profiles of individual patients.
In summary, while therapeutics currently holds the largest market share, R&D applications are emerging as the fastest-growing segment within the DNA synthesis market. Each application area is essential for advancing genetic research and biotechnological applications, contributing to the overall growth and development of the industry.
Market Revenue by Segment
| Market Revenue (M USD) in 2025 | ||
| By Type | Oligonucleotide Synthesis | 773.74 |
| Gene Synthesis | 685.58 | |
| By Application | Research and Development | 441.82 |
| Diagnostics | 436.81 | |
| Therapeutics | 580.70 |
5. Regional DNA Synthesis Market
North America remains a dominant player in the DNA synthesis market, driven by its strong research and development infrastructure, advanced technological capabilities, and robust biotechnology industry. In 2025, the region is projected to generate a revenue of $568.60 million. The presence of leading research institutions, universities, and biotech companies creates a favorable environment for innovation and market expansion. The U.S., in particular, is a major contributor to this revenue, with significant investments in personalized medicine and synthetic biology.
Europe is another significant contributor to the DNA synthesis market, with a projected revenue of $428.61 million in 2025. The region benefits from a well-established biotechnology industry, strong regulatory frameworks, and significant investments in research and development. European countries, such as Germany, the UK, and France, are at the forefront of genetic research and the development of novel DNA synthesis technologies. The demand for synthetic genes in diagnostics and therapeutics is also driving market growth in this region.
The Asia-Pacific region is emerging as a major market for DNA synthesis, with a projected revenue of $377.78 million in 2025. This growth is driven by the increasing demand for synthetic DNA in research and development, diagnostics, and therapeutics. Countries like China and Japan are leading the way, with significant investments in genomics and personalized medicine. The region’s rapid economic growth, coupled with advancements in biotechnology, is fueling the expansion of the DNA synthesis market.
The Middle East & Africa region is projected to generate a revenue of $34.07 million in 2025. While this region currently holds a smaller market share, it is experiencing significant growth driven by investments in healthcare infrastructure and the increasing prevalence of genetic disorders. The region’s growth is also supported by the global trend towards personalized medicine and the need for advanced diagnostic tools.
Latin America is projected to generate a revenue of $50.27 million in 2025. The region’s growth is driven by its rapidly developing economy and increasing investments in biotechnology and healthcare. Brazil and Mexico are key markets, with significant contributions to the region’s overall revenue. The demand for synthetic DNA in diagnostics and therapeutics is driving market expansion, supported by advancements in genetic research and the increasing prevalence of genetic disorders.
In terms of market share, North America holds the largest portion of the DNA synthesis market. This dominance is attributed to its strong research and development infrastructure and advanced technological capabilities. However, the Asia-Pacific region is emerging as the fastest-growing region. This rapid growth is driven by the region’s rapid economic development, significant investments in biotechnology, and the increasing demand for synthetic DNA in various applications.
Global DNA Synthesis Market Value (M USD) by Regions in 2025
6. Analysis of the Top 3 Companies in the DNA Synthesis Market
Company Introduction and Business Overview:
Eurofins Scientific is a global leader in food, environment, pharmaceutical, and cosmetic product testing, discovery pharmacology, forensics, advanced material sciences, and agroscience Contract Research services. Established in 1987 and headquartered in France, Eurofins operates across 61 countries with over 62,000 staff and approximately 900 laboratories. The company offers a wide range of analytical methods for evaluating biological substances and products, making it a key player in the genomics and clinical studies sectors.
Products Offered:
Eurofins provides comprehensive DNA synthesis services, including gene synthesis, oligonucleotide synthesis, and custom DNA constructs. Their proprietary software, GENEius, enables the optimization of synthetic genes for various applications, ensuring high-quality and reliable products.
In 2023, Eurofins Scientific reported a DNA synthesis revenue of $154.65 million.
Company Introduction and Business Overview:
Danaher Corporation is a global conglomerate that designs, manufactures, and markets medical, industrial, and commercial products and services. Established in 1969 and headquartered in the USA, Danaher operates through various subsidiaries, including Integrated DNA Technologies (IDT). The company is known for its lean manufacturing principles and continuous improvement strategies, making it a leader in the DNA synthesis industry.
Products Offered:
Danaher offers a wide range of DNA synthesis products and services, including gene synthesis, oligonucleotide synthesis, and custom DNA constructs. Their products are used in various applications, such as research and development, diagnostics, and therapeutics. Danaher’s acquisition of Aldevron in 2021 further expanded its capabilities in plasmid DNA, mRNA, and protein manufacturing.
In 2023, Danaher Corporation reported a DNA synthesis revenue of $150.88 million.
Company Introduction and Business Overview:
GenScript Biotech Corporation is a leading biotech company that provides life science research application instruments and services. Established in 2002 and headquartered in the USA, GenScript operates globally through its subsidiaries, including Legend Biotech, Probio Technology, and Bestzyme. The company’s main business segments include the CDMO platform, life-science services and products platform, integrated cell therapy platform, and industrial synthetic products platform.
Products Offered:
GenScript offers a wide range of DNA synthesis products and services, including gene synthesis, oligonucleotide synthesis, and custom DNA constructs. Their innovative GenCircle dsDNA synthesis service provides small circular double-stranded DNA vectors without resistance markers, enhancing the safety and efficiency of gene and cell therapy research.
In 2023, GenScript Biotech Corporation reported a DNA synthesis revenue of $127.88 million.
Major Players
| Company Name | Headquarter | Sales Region |
| Eurofins Scientific | France | Americas, Europe, APAC |
| Danaher | USA | North America, Europe, APAC |
| GenScript Biotech Corporation | USA | Worldwide |
| Thermo Fisher Scientific | USA | Worldwide |
| Twist Bioscience | USA | Worldwide |
| Bioneer Corporation | Korea | Worldwide |
| Azenta | USA | Worldwide |
| LGC Biosearch Technologies | UK | Worldwide |
| Biomatik | Canada | Worldwide |
| Eton Bioscience | USA | Worldwide |