1 Global Protein Sequencer Market Scope
The global protein sequencer market is projected to reach a total value of 51.54 million USD by 2025. The market has experienced steady growth over the past few years, with a Compound Annual Growth Rate (CAGR) of 1.42% from 2025 to 2030.
Protein sequencing is a crucial technique in the field of proteomics, enabling researchers to determine the amino acid sequences of proteins. This process is vital for understanding protein structure and function, which in turn supports advancements in drug discovery, disease diagnosis, and personalized medicine. The market’s growth is driven by increasing demand for protein biomarkers in drug development and continuous technological advancements in sequencing technologies.
Figure Global Protein Sequencer Market Revenue and CAGR 2025-2030
2 Drivers and Constraints of Protein Sequencer Market Growth
The market for protein sequencers is influenced by several key drivers and constraints. On the positive side, the growing need for protein sequencing in the pharmaceutical and biotechnology sectors is a significant driver. The development of new drugs, particularly biopharmaceuticals, relies heavily on detailed protein sequence analysis. Additionally, advancements in sequencing technologies, such as mass spectrometry and Edman degradation, have improved the accuracy and efficiency of protein sequencing, further fueling market growth. Government investments in proteomics research and the increasing focus on structure-based drug design also contribute to the market’s expansion.
However, the market faces several challenges. The high cost of sequencing instruments and the demand for highly skilled labor are major constraints. Protein sequencing requires sophisticated equipment and trained professionals to operate and analyze the data, which can be a barrier for some organizations. The COVID-19 pandemic has also had a significant impact on the market, disrupting supply chains and delaying research and development activities. Despite these challenges, the market is expected to continue growing due to the increasing importance of proteomics in life sciences research.
3 Protein Sequencer Market Technological Innovations and Mergers & Acquisitions Analysis
Technological innovations play a crucial role in the protein sequencer market. The development of advanced mass spectrometers and the integration of artificial intelligence (AI) in data analysis have significantly improved the efficiency and accuracy of protein sequencing. For example, Shimadzu’s release of Peakintelligence Ver. 2 software, which uses AI to detect chromatographic peaks, has streamlined the data analysis process and reduced the need for manual data correction.
Corporate mergers and acquisitions have also shaped the market landscape. Major players like Shimadzu have engaged in strategic acquisitions to expand their product portfolios and enhance their market positions. For instance, Shimadzu’s acquisition of Alsachim, a French company specializing in stable isotope-labeled compounds, has expanded Shimadzu’s offerings in the clinical market. Additionally, Shimadzu’s acquisition of CORE Medical Imaging, Inc., has strengthened its healthcare business in North America. These strategic moves have allowed Shimadzu to consolidate its position as a leading player in the protein sequencer market.
4 Global Protein Sequencer Market Analysis by Type
The global protein sequencer market is segmented into two primary types: Mass Spectrometry (MS) and Edman degradation.
Mass Spectrometry is a powerful analytical technique used in protein sequencing to determine the molecular weight and structure of proteins. By 2025, the MS segment is expected to reach a market size of 22.18 million USD, accounting for approximately 43.03% of the total protein sequencer market. The growth of the MS segment is driven by its high sensitivity and ability to analyze complex protein samples, making it indispensable in research and development activities in the pharmaceutical and biotechnology sectors.
Edman degradation is a classical method for protein sequencing that involves the stepwise removal of amino acids from the N-terminus of a protein. This method is known for its simplicity and reliability, particularly for sequencing smaller peptides. By 2025, the Edman degradation segment is projected to have a market size of 29.36 million USD, representing 56.97% of the total market. The continued use of Edman degradation is supported by its cost-effectiveness and suitability for specific applications where high-throughput sequencing is not required.
Table Global Protein Sequencer Market Size and Share by Type in 2025
|
Type |
Market Size (M USD) |
Market Share (%) |
|---|---|---|
|
MS |
22.18 |
43.03 |
|
Edman |
29.36 |
56.97 |
5 Global Protein Sequencer Market Analysis by Application
The global protein sequencer market is segmented into two primary applications: Biotherapeutics and Genetic Engineering.
Biotherapeutics involves the development of therapeutic proteins and peptides for medical treatments. By 2025, the biotherapeutics segment is expected to reach a market size of 85 units, accounting for approximately 33.73% of the total protein sequencer market. The growth of the biotherapeutics segment is driven by the increasing demand for protein-based drugs and the need for precise protein sequencing to ensure the efficacy and safety of these therapies. Protein sequencing plays a crucial role in the development and optimization of biotherapeutics, making this application a significant contributor to the market.
Genetic Engineering involves the manipulation of an organism’s genes to achieve desired traits or functions. By 2025, the genetic engineering segment is projected to have a market size of 167 units, representing 66.27% of the total market. The growth of the genetic engineering segment is driven by advancements in genetic research and the increasing need for protein sequencing to understand the genetic basis of diseases and develop gene therapies. Protein sequencing is essential in genetic engineering for identifying and modifying specific proteins involved in genetic processes.
Table Global Protein Sequencer Consumption and Share by Application in 2025
|
Application |
Consumption (Units) |
Market Share (%) |
|---|---|---|
|
Biotherapeutics |
85 |
33.73 |
|
Genetic Engineering |
167 |
66.27 |
6 Global Protein Sequencer Market Analysis by Region
The global protein sequencer market is a dynamic and evolving sector that plays a critical role in various fields such as biotherapeutics, genetic engineering, and proteomics research.
In terms of value market share, North America is anticipated to be the largest regional market, accounting for 33.84% of the total market. This region has consistently shown a strong inclination towards technological advancements and research investments, particularly in the pharmaceutical and biotechnology sectors. The presence of major players in the protein sequencing industry, coupled with a robust healthcare infrastructure, positions North America as a dominant force in the market.
Following North America, Europe is expected to hold a significant share of the market, with a projected 29.34% of the total value in 2025. Europe’s strong focus on research and development, along with supportive regulatory frameworks for biopharmaceuticals, contributes to its substantial market share. Additionally, the region’s high-quality research institutions and a skilled workforce further bolster its position in the protein sequencer market.
The Asia Pacific region is projected to have the fastest growth rate, with its market share increasing from 27.99% in 2020 to 31.44% in 2025. This growth can be attributed to the rapid industrialization and modernization of countries like China and India, which are increasingly investing in life sciences research. The region’s growing middle class and increased healthcare spending also contribute to the rising demand for protein sequencers. Moreover, governments in the Asia Pacific are implementing policies to foster innovation and technology adoption, which are expected to drive market growth in the coming years.
Figure Global Protein Sequencer Revenue Market Share by Region in 2025
7 Global Protein Sequencer Market: Top Companies Analysis
The global protein sequencer market is a specialized segment within the broader life sciences and analytical instrumentation industry. It is characterized by a few dominant players who contribute significantly to the market’s technological advancements and product offerings.
7.1 Shimadzu Corporation
Introduction and Business Overview:
Shimadzu Corporation is a renowned Japanese company established in 1875 with its headquarters mainly in Asia. The company has a global market distribution and is known for its precision tools and equipment. Shimadzu develops, manufactures, and sells a wide range of analytical and measuring instruments, medical systems, and aircraft and industrial equipment. The company’s commitment to research and development has positioned it as a leader in providing advanced solutions for various scientific and industrial applications.
Products Offered:
Shimadzu offers a comprehensive suite of products for protein sequencing, including:
PPSQ-51A/53A: These instruments are designed for determining the amino acid sequences of proteins and peptides. They combine an Edman reaction section with a high-performance liquid chromatograph (HPLC). The PPSQ-51A is equipped with one reactor, while the PPSQ-53A has three reactors, allowing for the continuous analysis of multiple samples. The Edman reaction section cleaves amino acids from the N-terminal of a protein through repeated Edman degradation, producing stable PTH-amino acids. These are then injected into the HPLC for analysis, with the data processed using specialized software to identify amino acids and estimate sequences.
LCMS-8060NX: This is a triple quadrupole liquid chromatograph mass spectrometer (LC-MS/MS) that uses artificial intelligence (AI) to enhance peak detection in chromatograms. The software, Peakintelligence Ver. 2, reduces the need for manual data correction and increases efficiency in research practices. This product is compatible with several Method Packages, including Primary Metabolites, Cell Culture Profiling, and Residual Pesticides, and is designed to work seamlessly with Shimadzu’s other analytical instruments.
Nexera UC: This is a high-performance liquid chromatography system that offers advanced separation technologies. It is used in conjunction with Shimadzu’s mass spectrometers to provide comprehensive analytical solutions for protein sequencing and other applications. The system is known for its reliability, ease of use, and ability to handle complex samples.
Prominence iHPLC System: This integrated HPLC system is designed for high-speed, high-resolution separations. It is suitable for a wide range of applications, including protein sequencing, where precise separation of compounds is crucial for accurate analysis.
Shimadzu’s product portfolio is characterized by its integration of advanced technologies such as AI and robust hardware capable of handling complex analytical tasks. The company’s focus on innovation and quality has made it a trusted partner for researchers and industries that require precise protein sequencing solutions.